大麻衍生物及其类似物用于治疗自闭症谱系障碍的治疗用途:系统性审查
Rachel Riera1,2, Isabela Porto de Toledo1, Cecília Menezes Farinasso1
1Hospital Sírio-Libanês (HSL), São Paulo, SP, Brazil.
Journal of clinical pharmacology
|July 3, 2025
概括
大麻可能有助于一些自闭症症状,但证据有限. 需要更多的研究来证实自闭症谱系障碍治疗的益处和安全性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 发育儿科 发育儿科
背景情况:
- 自闭症谱系障碍 (ASD) 涉及社会,沟通和行为挑战.
- 新兴研究表明,大麻对ASD症状具有潜在的治疗作用.
研究的目的:
- 系统地审查关于用于自闭症的大麻衍生物的随机对照试验 (RCT).
- 评估基于大麻的治疗方法在ASD患者的疗效和安全性.
主要方法:
- 根据"科克伦手册"和PRISMA 2020指南进行系统审查.
- 搜索了涉及大麻和ASD参与者的RCT的数据库.
- 包括11个RCT,其中4个报告了儿童/青少年的结果.
主要成果:
- 一项试验表明,大麻可以改善ASD的整体评估症状.
- 其他结局的结果是不确定的,没有评估生活质量.
- 对评估结果的证据确定性从非常低到低不等.
结论:
- 目前关于大麻治疗自闭症的证据有限,确定性低.
- 不同的大麻表现和结果措施阻碍了最终的结论.
- 不确定性影响了临床实践和关于使用大麻治疗ASD的决策.
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