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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Updated: Sep 17, 2025

Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
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西格莱克斯:从生物调节到免疫疗法

Jia Chen1,2, Yumin Huang2, Yafei Wang2

  • 1College of Life Sciences, Northwest University, Xi'an, 710069, China.

Current protein & peptide science
|July 3, 2025
PubMed
概括

酸结合性免疫球蛋白类讲蛋白 (Siglecs) 是疾病中的关键免疫调节剂. 向Siglecs显示出在癌症和自身免疫性疾病中新型免疫疗法的前景.

关键词:
希格莱克斯 (Siglecs) 是一个符号.免疫检查点是一个检查点.免疫调节 免疫调节 免疫调节免疫疗法. 免疫疗法.酸是酸的一种.

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科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 癌症研究 癌症研究

背景情况:

  • 西格莱克 (Sialic acid-binding immunoglobulin-like lectins) 是免疫细胞的受体,它们调节炎症和癌症免疫力.
  • 目前的Siglec向免疫疗法尽管在临床试验中进展,但其作用有限.

研究的目的:

  • 审查Siglec在人类疾病中的作用.
  • 探索针对Siglec-酸轴的新型治疗策略.

主要方法:

  • 在PubMed,科学网络和谷歌学者 (2015-2025) 的系统文献搜索.
  • 包括关于Siglec生物学,免疫调节和治疗潜力的研究.
  • 排除不相关的研究和未经同行评审的材料.

主要成果:

  • 西格莱克表现出双重免疫功能 (激活/抑制),并与癌症,自身免疫性疾病和病毒感染有关.
  • 西格莱克15和西格莱克10在癌症中充当免疫检查点.
  • 西格莱克2和西格莱克10涉及到像SLE这样的自身免疫性疾病.

结论:

  • 西格莱克是细胞与细胞和病原体相互作用的关键免疫调节剂,对人类疾病至关重要.
  • 向Siglecs为癌症和自身免疫性疾病提供了有前途的治疗途径.
  • 需要进一步的研究才能充分利用Siglec机制和临床应用.