在 Pseudomonas Aeruginosa 中的抗菌耐药性模式从慢性辅助性中耳炎中隔离出来
Sadaf Razzak1,2,3, Muhammad Sohail4, Fakhur Uddin
1Department of Pathology, Sindh Medical College, Jinnah Sindh Medical University, Karachi, Pakistan.
概括
Pseudomonas aeruginosa 是慢性性中耳炎 (CSOM) 的常见原因,通常与金黄色葡萄球菌 (Staphylococcus aureus) 共同感染. 对常见抗生素的高耐药性需要有针对性的管理,以获得更好的CSOM结果.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性性中耳炎 (CSOM) 是一种持续的中耳感染.
- Pseudomonas aeruginosa 在各种感染中是一个重要的机会性病原体.
- 了解P. aeruginosa在CSOM中的流行和耐药性对于有效治疗至关重要.
研究的目的:
- 为了确定P. aeruginosa在CSOM患者中的频率.
- 评估P. aeruginosa分离物的抗微生物敏感性模式.
- 在CSOM中识别与P. aeruginosa相关的潜在风险因素.
主要方法:
- 一项涉及巴基斯坦卡拉奇302名CSOM患者的横截面研究.
- 耳部泄漏样本进行培养,以鉴定病原体.
- 对P. aeruginosa的抗微生物敏感性测试遵循CLSI (2022) 准则;用于统计分析的奇平方测试.
主要成果:
- 在46.7%的CSOM病例中发现了P. aeruginosa,通常与金黄色葡萄球菌有关.
- 对皮佩拉西林 (46.1%),塞夫塔齐迪姆 (35.5%) 和塞费皮姆 (34.8%) 观察到高耐药率.
- 发现了对卡巴胺的耐药性 (24.8%的伊米,22%的美罗),而对胆固醇没有耐药性.
结论:
- P. aeruginosa是CSOM中占主导地位的病原体,经常与S. aureus一起感染.
- 对常见抗生素显著的抗菌耐药性突显了治疗挑战.
- 针对性的抗生素管理和干预措施对于管理P. aeruginosa在CSOM中至关重要.
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