硫空缺丰富的Bi2S3-x-Pt异构连接具有多酶活性,用于增强的声动疗法
Wanying Sun1, Xiaoxiao Yan1, Yingshu Li1
1Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, P. R. China.
ACS nano
|July 3, 2025
概括
研究人员用硫空缺和纳米粒子对硫化物 (Bi2S3) 进行了工程设计,以改进声动疗法 (SDT). 这一策略通过优化电子孔分离和减轻瘤缺氧来增强用于癌症治疗的活性氧物种 (ROS) 生成.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 硫化物 (Bi2S3) 由于其狭窄的带隙,显示出对声动疗 (SDT) 的希望.
- 在Bi2S3中的快速电子孔重组限制了其在产生反应性氧物种 (ROS) 的效率.
研究的目的:
- 通过改善电子孔分离和ROS生产来增强 bismuth sulfide 的声动疗效.
- 通过结合材料工程和纳米粒子功能化来开发针对性癌症治疗的新型纳米平台.
主要方法:
- 硫空缺工程被用来创建Bi2S3-x,并增强了电子孔分离.
- 在Bi2S3-x上培养了 (Pt) 纳米粒子,形成了肖特基异质连接,进一步改善了电子孔分离和催化活性.
- 该Bi2S3-x-Pt纳米平台被修改为氨酸 (HA) 以有针对性地传递到CD44过度表达的瘤细胞.
主要成果:
- 在Bi2S3-x中的硫空缺显著改善了超声波 (US) 照射下的电子孔对分离和ROS生成.
- Bi2S3-x-Pt Schottky异质连接增强了电子捕获和美国诱导的ROS生产.
- Pt纳米颗粒表现出类似甲基酶和过氧酶的活动,减轻瘤缺氧并增加单点氧生成.
- Bi2S3-x-Pt@HA通过重塑瘤微环境和诱导氧化应激,证明了显著的瘤抑制.
结论:
- 硫空位工程和Pt纳米粒子集成有效地提高了Bi2S3.3的声动力学性能.
- 开发的Bi2S3-x-Pt@HA纳米平台通过改善ROS生成和克服瘤缺氧,显示了针对性癌症治疗的潜力.
- 这项研究提出了优化无机声敏剂以提高治疗效果的有希望的策略.
相关概念视频
Preparation and Reactions of Sulfides
5.1K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
5.1K
Sulfur Assimilation
79
Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to...
79


