在患有糖尿病的儿童中,对乙型肝炎,麻疹,疹和红疹的血清保护
Maruti Haranalli1, Sangeeta Yadav1, Aashima Dabas1
1Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi 110002, India.
Journal of tropical pediatrics
|July 3, 2025
概括
与健康对照组相比,患有1型糖尿病 (T1DM) 的儿童对疫苗可预防的疾病 (如乙型肝炎和麻疹) 的血清保护水平较低,尽管在统计学上并不显著. 建议在T1DM中监测疫苗免疫力.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 疫苗可预防的疾病 (VPD) 对儿童构成重大风险,特别是在发展中国家.
- 1型糖尿病 (T1DM) 是一种慢性疾病,影响儿童,可能影响他们的免疫反应.
研究的目的:
- 在被诊断为T1DM的儿童中评估对常见VPD的血清保护状态.
- 为了比较T1DM儿童的抗体标位与年龄和性别匹配的健康对照.
主要方法:
- 招募了38名患有T1DM的儿童 (3-18岁) 和40名健康对照.
- 收集人口统计,临床数据和静脉血液样本.
- 测量了乙肝和麻疹,疹和红疹 (MMR) 疫苗的糖化血红蛋白 (HbA1c) 和抗体标位.
主要成果:
- 与对照组相比,患有T1DM的儿童对乙型肝炎 (42.5%) 和麻疹 (32.5%) 的血清保护率较低 (分别为55%和50%),但在统计学上并不显著.
- 在T1DM儿童中,B型肝炎和麻疹的抗体水平低于血清保护截止值,低于对照组.
- 在T1DM病例中,年龄与抗麻疹,抗疹和抗红疹标位有正相关性.
结论:
- 患有T1DM的儿童可能对某些VPD的血清保护降低,需要进一步调查.
- 医疗保健提供者应考虑监测T1DM患者的B型肝炎和MMR疫苗免疫力.
- 需要进一步的大规模研究来证实这些发现,并指导强剂疫苗接种策略.
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