淋巴状鼻瘤 - 一种与众不同的 (第四种) 亚型,通常与低风险的人类乳头瘤病毒有关
Ansa Mehreen1, Mitra Mehrad1,2, Kim A Ely1
1Department of Pathology, Microbiology, and Immunology.
The American journal of surgical pathology
|July 3, 2025
概括
一种独特的副类型的鼻瘤 (SP) 带有带状的特征,与低风险的人类乳头瘤病毒 (lrHPV) 密切相关,在吸烟者中显示出高恶性转变率.
科学领域:
- 病理学 病理学 病理学
- 在瘤学瘤学.
- 病毒学 病毒学
背景情况:
- 倒置乳头瘤 (IP) 是一种良性鼻瘤,具有复发风险和癌症潜力.
- 新出现的数据将一些IP与EGFR突变和低风险人乳头瘤病毒 (lrHPV) 联系起来.
- IPs中的状状特征表明一个独特的亚型,类似于生殖器状状瘤.
研究的目的:
- 为了研究带状形形态的鼻腔乳头瘤 (SP).
- 探索与lrHPV的关联,临床病理特征和癌瘤的发展.
- 确定这些瘤是否代表了具有增加恶性潜力的明显的SP亚型.
主要方法:
- 追溯分析了17个具有状形态的SP病例.
- lrHPV和高风险HPV (hrHPV) 的RNA在位杂交.
- p16 免疫组织化学,临床数据和后续审查.
主要成果:
- 阴道状乳头瘤主要发生在活跃吸烟者中,大,位于鼻腔 (47%).
- 观察到转化为侵入性状细胞癌的高率 (29%).
- 瘤与转录活性lrHPV (94%) 呈现几乎均的关联,并且是p16/hrHPV负的.
结论:
- 带带状形态的IP子组与lrHPV和鼻腔偏好有关.
- 与其他SP类型相比,这些瘤的恶性转变率显著更高.
- 这些发现支持将这些病变归类为具有高癌症风险的第四种单独的SP类型.
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