核心外PLGA微球的微流体调节用于持续释放烯酸
Ruoxin Wei1, Jiaze Dou1, Yihui Wu1
1Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, School of Chemical Engineering, East China University of Science and Technology, No. 130 Mei Long Road, Shanghai 200237, China.
Langmuir : the ACS journal of surfaces and colloids
|July 3, 2025
概括
这项研究开发了使用微流体进行持续烯酸释放的多 (乳酸-co-甘油酸) 微球. 优化条件实现了高封装效率和药物加载,以实现有效的递送系统.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 微流体技术技术 微流体技术
背景情况:
- 微球配方提供了一种可行的策略,可以提供治疗性蛋白质和,在体内半衰期短.
- 这些系统保护敏感的生物分子免受降解,提高它们的治疗效果.
- 聚乳-同-甘油酸 (PLGA) 微球在受控药物释放应用中得到了广泛的探索.
研究的目的:
- 开发使用微流体技术装载烯酸乙酸 (LA) 的聚乳-合-甘油酸 (PLGA) 微球.
- 在PLGA微球中研究影响LA封装效率 (EE) 和药物负载 (DL) 的关键参数.
- 描述开发的LA-PLGA微球的形态,颗粒大小和体外释放特征.
主要方法:
- 采用玻璃毛细管微流体装置,制造水在油在水 (W/O/W) 乳液.
- 不同度的凝 (Gel) 被纳入内部水相.
- 系统地评估了内部阶段的不同收集溶液和LA度.
主要成果:
- 单分散的LA-PLGA微球,具有大约80微米的均颗粒大小和独特的核心外结构,已成功制造.
- 在7.5mg/ml的凝度下,最大封装效率 (EE) 为80.28%和药物负载 (DL) 为4.24%得到了实现.
- 实验室释放研究表明,LA释放持续了大约28天,DL与初始LA度成比例增加.
结论:
- 微流体技术使LA-PLGA微球能够准确地准备和调节,以持续输送药物.
- 凝的结合和收集溶液的pH值是控制封装效率的关键因素.
- 开发的微流体战略为制备水溶性和蛋白质成为先进的药物递送系统提供了一个强大的平台.
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