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Updated: Sep 17, 2025

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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质母细胞瘤的恶性转变:一次一步

John J Y Lee1,2, Mario L Suvà1,2

  • 1Department of Pathology and Krantz Family Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Cancer discovery
|July 3, 2025
PubMed
概括

研究人员在神经干细胞逐渐转化为质母细胞瘤的过程中确定了癌前细胞阶段. 这一发现为早期癌症发展和潜在的治疗点提供了新的见解.

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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