MASLD和其他代谢疾病的全球负担不断增加 (2000-2021)
Pojsakorn Danpanichkul1, Kanokphong Suparan2, Luis Antonio Diaz3,4,5
1Department of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA.
代谢性疾病,包括与代谢功能障碍相关的脂肪性肝病 (MASLD) 和2型糖尿病 (T2DM),构成了全球重大健康挑战. 趋势显示,MASLD和T2DM的流行率越来越高,男性和中低SDI国家的负担更高,需要政策干预.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 代谢疾病 代谢疾病
背景情况:
- 代谢性疾病是一个关键的全球公共卫生问题.
- 这项研究分析了代谢性疾病不断变化的流行病学景观.
研究的目的:
- 更新全球各地区的代谢性疾病的流行病学趋势,包括MASLD和T2DM.
- 通过使用"2021年全球疾病负担研究"来研究这些由社会人口因素分层的趋势.
主要方法:
- 专注于与代谢功能障碍相关的脂肪性肝病 (MASLD),2型糖尿病 (T2DM),肥胖,高血压和脂质不良.
- 使用年龄标准化率 (ASRs) 估计的患病率和经残疾调整的寿命年 (DALYs).
- 分析了2000-2021年使用Joinpoint回归的趋势,按性别,地理和社会人口统计指数 (SDI) 分层.
主要成果:
- 在2021年,MASLD影响全球1.270亿,T2DM影响0.51亿.
- 在过去二十年中,MASLD和T2DM的年龄标准化流行率有所增加.
- 根据残疾调整的寿命年数在失脂症和高血压下降,但在T2DM和肥胖中增加;MASLD保持稳定. 在男性和低中等SDI国家中观察到更高的负担.
结论:
- 全球MASLD和相关代谢疾病的负担很大.
- 迫切需要加强国家和全球政策,以应对MASLD和其他代谢性疾病对公共健康的威胁.
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