分析发育中的大脑的纵向变化模式使用功能和结构磁共振成像通过多模式融合
Rekha Saha1, Debbrata K Saha1, Zening Fu1
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS) Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, Georgia, USA.
Human brain mapping
|July 3, 2025
概括
功能性和结构性MRI的结合揭示了青少年大脑的关键变化. 这项研究将功能变化模式与大脑结构联系起来,揭示神经发育中的性别特异性差异,以便全面理解.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 青少年大脑发育涉及功能和结构的复杂纵向变化.
- 功能性MRI (fMRI) 和结构性MRI (sMRI) 提供了互补的见解,但通常被孤立地研究.
- 之前的工作已经确定了青春期多变量功能变化模式 (FCPs).
研究的目的:
- 通过多式联,将之前识别的FCP与结构模式联系起来.
- 调查青少年时期大脑功能和结构的结合中性别特异性的差异.
- 通过整合fMRI和sMRI,更全面地了解青少年大脑发育.
主要方法:
- 在青少年大脑和认知发展 (ABCD) 数据集中应用了两种多式融合方法.
- 评估voxel-wise的sMRI-FCP不对称性合,以确定与FCP相关的结构模式.
- 采用多组合法定相关性分析 (mCCA) +联合独立组件分析 (jICA) 进行对称的多式联.
主要成果:
- 确定了FCP和灰色物质体积 (GMV) 变化之间的显著关联.
- 发现了与结构变化模式 (SCP) 相关的结构化FCP,包括感觉运动皮层的变化.
- 与男性相比,在女性中观察到更强的功能-结构大脑连接性合.
结论:
- 结合不对称和对称的融合方法在青春期揭示了复杂的,特定于性别的神经动态.
- 多模式集成增强了对不断变化的全脑连接和结构的理解.
- 这项研究揭示了青少年大脑发育背后的细微过程.
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