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在人体衰老过程中,血液细胞中的拉胺A/C表达减少,并在小鼠中抑制动脉样硬化

Marta Amorós-Pérez^1,2, Alberto Del Monte-Monge^1,2, Pilar Gonzalo^1,2

¹Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (M.A.-P., A.D.M.-M., P.G., M.J.A.-M., C.R., V.F., C.G.-G., A.B., A.D., F.S.-C., C.T., F.M.d.B., H.B., J.J.F., V.A.).

Arteriosclerosis, thrombosis, and vascular biology

|July 3, 2025

概括

衰老会降低免疫细胞中的膜A/C,促进动脉样硬化. 在造血细胞中降低层层A/C加速了这种疾病,而增加它提供了保护,揭示了一个新的治疗点.

科学领域:

分子生物学分子生物学
免疫学免疫学免疫学
心血管疾病心血管疾病

背景情况:

衰老是动脉样硬化的主要危险因素,是全球死亡的主要原因.
以前的研究通过核膜缺陷 (A型层) 将过早衰老综合征与动脉样硬化联系在一起.
在正常衰老过程中,膜在动脉样硬化中的作用以前未被探索.

研究的目的:

为了研究衰老对循环白细胞中层A/C表达的影响.
确定操纵血液细胞中的层状A/C表达对免疫细胞功能和动脉样硬化进展的影响.

主要方法:

流细胞计测试以评估人体白细胞中的层层A/C表达.
在Ldlr-/-小鼠中进行骨髓移植,以模拟动脉样硬化和白细胞扩散.
使用了肠道显微镜,油红色O染色和单细胞RNA测序.

主要成果:

人类的衰老与白细胞中层A/C表达的减少有关.
拉胺A/C缺乏的骨髓移植加速了动脉样硬化和白细胞扩散.
骨髓过度表达的层层A减少白细胞扩散和动脉样硬化.

结论:

白细胞层A/C与年龄相关的下降有助于动脉样硬化.
拉A/C作为与年龄相关的动脉样硬化的一种新型调节剂.
调节造血细胞层A/C影响免疫细胞和内皮细胞的功能.

关键词:

老化的老化衰老的老化动脉样硬化动脉样硬化心血管疾病心血管疾病这是一种炎症炎症炎症炎症.层类型A 类型A.单细胞基因表达分析分析

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