胃切除术引起的肠道微生物群的变化与口腔和胃微生物群的变化有关
Eri Komori1, Nahoko Kato-Kogoe1, Yoshiro Imai2
1Department of Dentistry and Oral Surgery, Faculty of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki, Osaka, Japan.
Frontiers in microbiology
|July 3, 2025
概括
胃切除术改变了肠道微生物群的多样性,增加了像Rothia和Lactobacillus这样的有益细菌. 这些变化与口腔和胃微生物群的变化有关,影响了手术后整体消化健康.
科学领域:
- 微生物组研究的研究.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 胃癌治疗通常涉及胃切除术,导致消化道发生重大变化.
- 肠道微生物群在术后健康中起着至关重要的作用,但其在胃切除术后与口腔和胃微生物群的相互作用尚不清楚.
研究的目的:
- 为了描述胃切除术后肠道微生物群的变化.
- 评估这些肠道微生物群变化与口腔/胃微生物群之间的关联.
主要方法:
- 在胃切除术前和6个月后从胃癌患者收集唾液,胃液和便样本.
- 进行了16S rRNA元基因组测序,并使用LEfSe.Se分析了微生物的多样性和丰富性.
主要成果:
- 肠道微生物群的多样性在胃切除术后显著增加 (香农指数,p=0.044).
- 在肠道微生物群中增加了*Rothia*和*Lactobacillus*的丰度.
- 在手术后的肠道,口腔和胃样本中, *Rothia* 和 *Lactobacillus* 的流行率增加.
结论:
- 胃切除术诱导肠道微生物群组成的显著变化.
- 肠道微生物群的变化与胃切除术后的口腔和胃微生物群相互联系.
- 这些发现阐明了宿主微生物群相互作用,以应对手术后改变的胃环境.
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