8岁儿童大脑白质的发育与怀孕期间母亲的心理健康有关
Yali Huang1, Timothy R Koscik2,3, Aline Andres2,4
1Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Frontiers in human neuroscience
|July 3, 2025
概括
产前母亲的抑郁和焦虑与8岁时儿童的边缘系统中白质微观结构的改变有关. 这些发现强调了母亲心理健康对儿童长期神经发育的重要性.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 孕产妇健康 孕产妇健康
背景情况:
- 怀孕期间母亲的心理健康显著影响胎儿的大脑发育.
- 产前母亲心理健康状况对后代的长期影响尚未完全理解.
- 这项研究重点关注产前母亲抑郁/焦虑和儿童白质微观结构之间的关联.
研究的目的:
- 研究怀孕期间母亲抑郁和焦虑症状与8岁儿童边缘系统白质微观结构之间的关系.
- 探索产前母亲心理健康对儿童大脑发育的持久影响.
- 为了识别受产前母亲心理健康影响的边缘系统中的特定白质道.
主要方法:
- 对51个母婴二合体进行前性,纵向研究.
- 在怀孕期间使用贝克抑郁 inventory-II (BDI-II) 和国家轨道焦虑 inventory (STAI) 评估母亲抑郁和焦虑.
- 儿童在8岁时接受了脑部MRI,使用扩散张力成像 (DTI),扩散性皮质成像 (DKI) 和神经元定向分散和密度成像 (NODDI) 进行分析,以评估边缘白质微观结构 (例如,FA,MD,MK,NDI).
主要成果:
- 较高的孕产妇抑郁分数与较低的分数异构 (FA) 和平均缩 (MK),以及右半球边缘通道中较高的平均扩散率 (MD) 和辐射扩散率 (RD) 相相关.
- 较高的孕产妇焦虑分数与增加的MD和RD相关,神经密度指数 (NDI) 降低,左半球边缘道中轴性皮质变化 (AK) 增加.
- 特别的关联被观察到在环,,和未经结的带.
结论:
- 产前母亲的抑郁和焦虑与子女在边缘系统内白质微观结构的长期变化有关.
- 这些发现强调了对产前心理健康查和干预的急需.
- 在怀孕期间支持母亲的心理健康对于促进健康的儿童神经发育结果至关重要.
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