持续的短时间或长时间睡眠时间预测中风后抑郁症中风和过渡性缺血性发作后的一年
Yang Hu1, Lijun Zuo1, Yuesong Pan2
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
Nature and science of sleep
|July 3, 2025
概括
在急性缺血性中风 (AIS) 或短暂缺血性发作 (TIA) 后睡眠时间的变化影响恢复. 持续的异常睡眠或新开发的长/短睡眠持续时间与中风后抑郁症和功能表现不佳的更高风险有关.
科学领域:
- 神经学 神经学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 睡眠时间受损是已知的中风风险因素,也是抑郁症的预测因素.
- 在急性缺血性中风 (AIS) 或短暂缺血性发作 (TIA) 后,睡眠时间的变化对功能结果和抑郁症的影响仍然不清楚.
研究的目的:
- 研究睡眠时间的变化与中风后抑郁症 (PSD) 的风险,生活质量和AIS或TIA后一年的功能结果之间的关联.
主要方法:
- 分析了来自中国国家中风注册III (ICONS研究) 的1450名AIS或TIA患者队列.
- 睡眠时间分为正常 (7-8小时),短 (<7小时) 或长 (≥9小时).
- 根据睡眠时间的变化将患者分组为组:持续正常,变为正常,从正常变化,持续异常. 使用后勤回归来评估1年随访后的结果.
主要成果:
- 与持续正常睡眠相比,持续长时间或短时间的睡眠时间与显著更高的PSD风险 (OR 1.58) 和生活质量差 (OR 1.42) 相关.
- 睡眠时间减少 (>1小时) 增加了中度至重度PSD的风险 (OR 2.26).
- 新开发的异常睡眠时间 (从正常变为长/短) 与较高的功能结果差的风险有关 (OR 2.82).
结论:
- 睡眠时间的变化与PSD,生活质量差以及AIS或TIA一年后的不良结果独立相关.
- 睡眠量不足在长期抑郁,生活质量和中风后功能恢复方面发挥着重要作用.
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