卡拉对代谢综合征相关参数的影响:系统性审查和元分析
Ajaree Rayanakorn1,2, Pattarachon Apisitwittaya2, Shaun Wen Huey Lee3
1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Frontiers in pharmacology
|July 3, 2025
概括
成年人使用克拉与较低的LDL胆固醇,甘油三和BMI有关,HDL胆固醇较高. 需要进一步的研究来证实这些代谢效应.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 米特拉吉纳特种植物 (kratom) 是一种热带植物,以类似阿片类药物的特性和代谢作用而闻名.
- 关于 kratom 对代谢综合征 (MetS) 参数的影响的数据有限.
- 这项研究系统地审查了 kratom 对人类代谢健康的影响.
研究的目的:
- 系统地审查和元分析 kratom 消费对人类代谢综合征参数的影响.
- 调查卡拉使用与关键代谢指标之间的关联.
主要方法:
- 在PubMed,科学网络,Embase和Cochrane图书馆进行了系统的文献搜索,截至2024年9月6日.
- 包括了研究 kratom 消费和代谢影响的符合条件的分析研究.
- 随机效应模型被用来组合效应估计 (平均差异与95%置信区间).
主要成果:
- 分析了五项涉及1458名成年人的横截面研究.
- Kratom 使用与血清低密度脂蛋白胆固醇 (LDL-c) 和甘油三 (TG) 水平显著降低有关.
- 在kratom使用者中观察到高密度脂蛋白胆固醇 (HDL-c) 和较低的体重指数 (BMI) 的较高.
结论:
- 成年人使用克拉与LDL-c,TG,BMI和HDL-c的有利变化有关.
- 没有发现对总胆固醇或血糖水平有统计学意义的影响.
- 克拉可能对某些代谢风险因素提供保护性益处,这需要进一步的纵向研究.
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