超重和Helicobacter pylori感染:与代谢功能障碍相关的脂肪肝疾病的相关性
Xu Chen1, Jiayue Fu2,3, Kejia Jin3,4
1Department of Medical Care Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Frontiers in cellular and infection microbiology
|July 3, 2025
概括
杆菌感染与超重的中国成年人中代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有关. 根除H. pylori可能有助于减少超重的MAFLD发病率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是一个日益严重的健康问题,最近取代了非酒精性脂肪肝疾病 (NAFLD).
- 杆菌 (H. pylori) 感染很普遍,并且越来越多地与胃外疾病有关.
- 在中国人群中,H. pylori和MAFLD之间的关系以前未被探索.
研究的目的:
- 调查中国队伍中H. pylori感染和MAFLD之间的关联.
- 探索特定子组内的潜在相关性,例如超重个体.
主要方法:
- 对5619名参与者进行了一项回顾性横截面研究.
- 使用13C尿素呼吸测试或胃活检检测出H. pylori感染.
- MAFLD的诊断是基于超声波和代谢指标,用于分析的后勤回归.
主要成果:
- 在一般人群中,H. pylori和MAFLD之间没有发现显著的总体关联.
- 亚组分析显示,超重个体与MAFLD有显著的关联 (p=0.002).
- 在调整为混因子 (OR=1.957,p=0.010) 后,超重的MAFLD患者中的这种关联仍然显著.
结论:
- 患有MAFLD的超重个体表现出H.pylori感染的更高患病率.
- 在超重状态,H. pylori感染和MAFLD进展之间存在潜在的有害循环.
- 根除H. pylori可能是减少超重MAFLD发病率的治疗策略.
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