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在治疗急性主观耳患者中使用普得尼松的随机对照试验,其纯色度值正常
Peifan Li1, Chenhao Che1, Dantong Gu1
1ENT Institute and Department of Otorhinolaryngology, NHC Key Laboratory of Hearing Medicine Research, Eye & ENT Hospital, Fudan University, Shanghai 200031, China.
iScience
|July 3, 2025
概括
短期口服普雷迪尼松 (STOP) 与金科比洛巴结合,有效地减少了急性主观耳 (AST) 患者的耳严重程度. 与安慰剂相比,这种治疗在12周内显著改善了耳障碍清单得分.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 药理学 药理学是指药理学的学科.
背景情况:
- 没有突然听力损失的急性主观耳 (AST) 是一种有争议的治疗选择的疾病.
- 类固醇治疗AST的疗效需要进一步研究.
研究的目的:
- 评估短期口服普得尼松 (STOP) 治疗AST的有效性.
- 评估STOP与金科比洛巴结合对耳严重性的影响.
主要方法:
- 进行了一项随机对照试验.
- 参与者接受了14天的普得尼松加银杏或安慰剂加银杏的逐渐减少疗程,持续3个月.
- 主要结局是12周耳障碍库存 (THI) 评分的变化.
主要成果:
- 在12周后,STOP组的THI分数 (-27.34) 与对照组 (-15.37) 相比显著降低.
- 两组之间的THI分数减少的平均差异为-11.97 (p < 0.0001).
- 敏感性和后期 hoc 分析支持了这些发现.
结论:
- 短期口服普雷尼松 (STOP) 与金科比洛巴结合是一种有效的治疗方法,可减少AST患者自我报告的耳严重程度.
- 这些发现表明,口服类固醇在治疗急性主观耳中具有潜在的治疗作用.
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