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高碳水化合物饮食计划在F2世代的代谢酶基因表达修饰 wistar老鼠雄性

Joseph Chimezie^1,2, Worship Odosa Agbonifo^1,2, Hope Oluwabukola Francis^1,2

¹Epigenetics and Molecular Biology Laboratory, Federal University of Technology, Akure, Nigeria.

Current research in physiology

|July 3, 2025

概括

高碳水化合物饮食对代谢健康产生负面影响. 父母的高碳水化合物饮食改变了后代的基因表达,甚至在没有饮食暴露的情况下也影响了代谢途径.

科学领域:

代谢健康代谢健康
基因表达基因表达基因表达
跨代的影响.

背景情况:

高碳水化合物饮食 (HCD) 与不良的代谢结果有关.
基因表达在代谢调节和表型中起着至关重要的作用.
了解跨代代谢影响对公共健康至关重要.

研究的目的:

研究HCD对代谢基因表达的跨代影响.
分析三个子代 (F0,F1,F2) 的代谢和表型变化.
为了确定父母的HCD是否影响后代的基因表达,无论他们的饮食.

主要方法:

鼠 (F0) 吃了对照或HCD饮食并交配.
后代 (F1和F2) 在控制或HCD饮食中产生和维持.
跨世代的男性后代对代谢参数和基因表达进行了分析.

主要成果:

在F1和F2世代中,HCD增加了体重,胰岛素和HOMA-IR.
HCD改变了糖解,糖原合成和脂肪酸代谢中的基因表达.
F2后代表现出改变的代谢基因表达模式,即使是在控制饮食中.

结论:

父母HCD诱导后代代谢基因表达的持久变化.
跨代代谢编程发生的独立于后代的饮食.
对表观遗传机制的进一步研究是有必要的.

关键词:

Filial 一代子代子代.基因表达基因表达基因表达高碳水化合物饮食高碳水化合物饮食代谢酶是代谢酶的组成部分.

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