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Updated: Sep 17, 2025

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抑制REV-ERBα表达可以防止机械过载引起的软骨时钟干扰和骨关节炎进展

Xiaojie Xu1,2, Dong Wang2, Bowei Ni2

  • 1College of Life Sciences, Northwest University, Xi'an, 710069, China.

Journal of orthopaedic translation
|July 3, 2025
PubMed
概括

异常的机械负荷扰乱了软骨的昼夜钟,增加了REV-ERBα,并导致骨关节炎 (OA). 抑制REV-ERBα或MAPK-MYC通路可以通过恢复昼夜节律来治疗OA.

关键词:
软骨和软骨是一种循环节的时钟是循环节的时间.机械刺激是一种机械刺激.骨关节炎是一种骨关节炎.这就是REV-ERBα.在SR8278中,您可以使用SR8278.

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