非酒精性脂肪肝疾病中的肠道微生物群:病理生理学,诊断和治疗方法
Himani Pandey1, Prabudh Goel2, Varunvenkat M Srinivasan3
1Department of Medical Genetics, Redcliffe Labs, Noida 201301, Uttar Pradesh, India.
World journal of hepatology
|July 3, 2025
概括
非酒精性脂肪性肝病 (NAFLD) 与肠道微生物群的变化有关. 调节肠道微生物组为NAFLD和相关代谢障碍提供了潜在的新疗法.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 微生物组研究 微生物组研究
- 代谢性疾病研究研究
背景情况:
- 非酒精性脂肪性肝病 (NAFLD),或代谢相关的脂肪性肝病,是一种广泛的慢性肝病.
- NAFLD可以发展为严重的肝损伤,包括肝硬化和癌症,并与代谢障碍有关,如2型糖尿病和肥胖.
- 肠肝轴起着至关重要的作用,肠道微生物群的改变与NAFLD的发展和进展有关.
研究的目的:
- 审查肠道微生物群在NAFLD病变发生中的关键作用.
- 探索针对NAFLD的肠道微生物群的诊断和治疗潜力.
主要方法:
- 在NAFLD中调查肠肝轴的研究的文献综述.
- 对肠道微生物群签名,代谢物及其与NAFLD病理生理学的联系的研究分析.
- 对NAFLD以微生物群为中心的治疗策略的检查.
主要成果:
- 肠道微生物群的改变和肠道屏障功能受损与NAFLD显著相关.
- 关键的微生物特征和代谢物通过氧化应激和内毒性等途径促进NAFLD.
- 饮食干预和治疗方法,如益生菌和便微生物群移植,显示出有希望的结果.
结论:
- 肠道微生物群失调是NAFLD发展和进展的关键因素.
- 准肠道微生物组为NAFLD诊断和治疗提供了一个有希望的途径.
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