门癌症对艾滋病毒感染者的影响 - 一个匹配的队列研究
Amanda Acioli de Almeida Robatto1,2, Erika Andrade Rocha1,3, Renata Colombo Bonadio1,4,5
1ICESP - Instituto do Câncer do Estado de São Paulo, Dr. Arnaldo Avenue, Sao Paulo 01246-000, Brazil.
Ecancermedicalscience
|July 3, 2025
概括
人类免疫缺陷病毒阳性 (HIV+) 癌患者接受化疗 (CRT) 的结果与HIV阴性患者的结果相似. 然而,由于毒性,艾滋病毒+个体需要更密切地监测医院入院的情况.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 临床研究 临床研究
背景情况:
- 对癌治疗化学辐射 (CRT) 的关键研究排除了人类免疫缺陷病毒阳性 (HIV+) 患者.
- 艾滋病毒状况对癌治疗结果的影响在很大程度上是未知的.
研究的目的:
- 研究用CRT治疗门癌症患者的结局,比较HIV阳性 (HIV+) 和HIV阴性 (HIV-) 个体.
- 评估CRT在HIV+癌患者的疗效和安全性.
主要方法:
- 从2010年到2021年,使用电子病历进行了回顾性匹配队列研究.
- 癌患者 (T1-4 N0-1 M0) 根据年龄,阶段和ECOG表现状况进行了选择和匹配.
- 总生存率 (OS) 是主要终点,使用卡普兰-梅尔曲线和日志等级测试进行分析.
主要成果:
- 在艾滋病毒+和艾滋病毒患者之间,没有观察到完全临床响应 (cCR),无复发生存 (RFS) 或整体生存 (OS) 的显著差异.
- 艾滋病毒+患者因毒性而入院的次数显著增加 (30%对13%).
- 结肠直肠切除和救援手术的发生率在两组之间相似.
结论:
- 化学辐射 (CRT) 对HIV+和HIV-门癌患者的cCR,RFS和OS具有可比的疗效.
- 虽然应该在HIV+个体中寻求最佳治疗,但由于住院的风险增加,加强临床监测至关重要.
- 对优化CRT协议的进一步研究对于艾滋病毒+人群是有必要的.
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