相关实验视频

Updated: Sep 17, 2025

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Published on: May 8, 2017

在类风湿性关节炎中准纤维细胞激活蛋白:从分子成像到精确治疗

Yupeng Huang¹, Yang Wu¹, Huan Liu²

¹Department of General Practice, General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Frontiers in immunology

|July 3, 2025

概括

纤维细胞激活蛋白 (FAP) 成像显示了对类风湿性关节炎 (RA) 的承诺. 针对FAP的治疗和成像,如FAPI PET/CT,可以诊断RA,监测疾病,并可能治疗炎症.

科学领域:

类风湿病学类风湿病学
在瘤学瘤学.
医疗成像医学成像

背景情况:

类风湿性关节炎 (RA) 是一种慢性炎症性疾病,导致关节的破坏.
激活的纤维细胞样同胞细胞 (FLS) 驱动RA的进展和炎症.
纤维细胞激活蛋白 (FAP) 在RA-FLS中表达高,但在正常组织中表达不高.

研究的目的:

审查RA诊断和评估的FAP向成像方面的进展.
突出FAP作为RA疾病监测和潜在治疗的生物标志物.
在瘤学之外探索针对FAP的治疗方法.

主要方法:

综述目前关于RA中FAP表达和向的研究.
讨论FAP抑制剂 (FAPI) PET/CT用于突炎可视化和治疗反应.
探索针对FAP的疗法,如放射性核素和光动力学疗法.

主要成果:

FAPI PET/CT精确可视化RA突炎,并监测治疗反应.
FAP成像检查评估了诸如肺部和心脏纤维化等关节外表现.
针对FAP的疗法在RA模型中显示出选择性消除致病细胞的潜力.

结论:

FAP是RA诊断和疾病评估的关键生物标志物.
针对FAP的成像提供了RA评估的非侵入性工具.
针对FAP的疗法代表了RA的一种有前途的治疗策略.

关键词:

FAPIAPI FAPIAPI 这是一个很好的方法.疾病评估疾病评估纤维细胞激活蛋白质的激活蛋白质类风湿性关节炎类风湿性关节炎治疗治疗治疗治疗治疗治疗

更多相关视频

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Generation of Induced-pluripotent Stem Cells Using Fibroblast-like Synoviocytes Isolated from Joints of Rheumatoid Arthritis Patients

Published on: October 16, 2016

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

相关概念视频

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...