在急性缺血性中风患者中,多病症与生物年龄加速的关联:一个横截面研究
Hanbing Zhao1,2, Yiwei Qian2, Yifang Zhou2
1Nursing and Health School, Zhengzhou University, Zhengzhou, China.
概括
多种病症显著加快了急性缺血性中风 (AIS) 患者的生物衰老. 代谢血管疾病,如高血糖和高血压,显示出与这种加速衰老过程的最强有力的联系.
科学领域:
- 老年学是一门学科.
- 心血管医学 心血管医学
- 神经学 神经学
背景情况:
- 在急性缺血性中风 (AIS) 患者中,多发病率很普遍.
- 多病症对AIS生物衰老的影响尚不清楚.
- 具体的多病症模式及其与加速衰老的关联需要研究.
研究的目的:
- 为了评估AIS患者的潜在多病症模式.
- 在AIS中量化多病症和生物衰老加速之间的关系.
- 确定与加速生物衰老相关的特定多病性群.
主要方法:
- 利用了来自2539名AIS患者 (2018-2019) 的数据.
- 使用Klemera-Doubal方法 (KDM-BA) 和表型年龄 (PhenoAge) 评估生物年龄.
- 使用潜伏类分析 (LCA) 进行多病性聚类和通用线性模型进行关联分析.
主要成果:
- 90%的AIS患者患有多病症 (≥2种疾病).
- 每种额外的慢性疾病与KDM增长的基于KDM的年龄加速 (+3.78年) 和PhenoAge加速 (+0.78年) 相相关.
- 超血糖-高血压模式显示,与基于KDM的衰老加速 (β=11.59) 有着最强的关联.
结论:
- 多种疾病在AIS中很常见,并且与加速的生物衰老有关.
- 代谢-血管多病态模式与加速衰老的最强相关性.
- 需要进一步的前性研究来确定AIS中的多病症和生物衰老加速之间的因果关系.
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