关于尼古丁蒸汽和自发流产的发生率的预设队列研究
Austen D Le1, Chiyuan Amy Zhang2, Abby L Chen1
1Stanford University School of Medicine, Stanford, CA, United States.
概括
任何伴侣的尼古丁vaping没有与自发流产 (SAB) 发生率的关联. 吸烟没有改变这种关系,这表明电子烟不是SAB的重要风险因素.
科学领域:
- 生殖健康 生殖健康
- 公共卫生 公共卫生
- 电子烟研究 电子烟研究
背景情况:
- 尼古丁vaping的流行率正在上升,促使对其生殖健康影响的审查.
- 关于怀孕前的电子烟的指导不如怀孕前的指导更不清楚,尽管怀孕前的行为对怀孕结果的影响.
研究的目的:
- 评估女性和男性伴侣在怀孕前的尼古丁vaping与自发流产 (SAB) 发生率之间的关联.
- 为了确定吸烟是否会改变电子烟和SAB之间的关系.
主要方法:
- 对6136名女性和1688名男性伴侣进行前性队列研究,报告了电子烟和吸烟的习惯.
- 使用考克斯比例危险回归来分析蒸汽和SAB发病率之间的关联.
- 调整以吸烟史和其他潜在的混因素.
主要成果:
- 没有发现女性或男性怀孕前的vaping和SAB发病率之间有显著的关联.
- 无论是前任还是现任合作伙伴的vaping都与SAB率的增加无关.
- 吸烟状态并没有改变吸烟和SAB之间的关联.
结论:
- 任何伴侣的尼古丁vaping都与自发流产无关.
- 这些发现表明,在SAB的背景下,怀孕前的电子烟可能不会带来重大风险,与怀孕期间的电子烟已知的风险形成鲜明对比.
- 需要进一步的研究,为夫妇提供全面的基于证据的信息,以了解怀孕前的vaping和生殖健康.
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