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双向风险协会 上腺炎和炎症性肠病之间
Louise Lönndahl1, Maria Najeeb2, Hassan Killasli3
1Dermato-Venereology Clinic, Karolinska University Hospital, Stockholm, Sweden; Dermatology and Venereology Division, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden.
Acta dermato-venereologica
|July 3, 2025
概括
补腺炎 (HS) 和炎症性肠病 (IBD) 分享双向风险. 患有HS的患者患上IBD的几率更高,反之亦然,尤其是克罗恩病.
科学领域:
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 补腺炎 (HS) 是一种慢性炎症性皮肤疾病.
- HS与并发症有关,包括炎症性肠病 (IBD),但证据有限.
- 在HS和IBD之间的双向关系需要进一步调查.
研究的目的:
- 调查HS和IBD之间的双向风险.
- 分析大规模的患者数据以确认关联.
- 为了量化患上一种疾病的风险增加,给出对另一种疾病的诊断.
主要方法:
- 一个大规模的,倾向性得分匹配的回顾性队列研究.
- 利用TriNetX平台与超过20万名HS患者和330万IBD患者进行了治疗.
- 分析了5年风险和危险比率 (HR) 与发展HS或IBD的置信区间 (CI).
主要成果:
- 在5年内,HS诊断将任何IBD诊断的风险增加36% (HR 1.356),克罗恩病的风险最高 (HR 2.501).
- IBD诊断增加了31%的HS风险 (HR 1.313),克罗恩病再次显示出最强的关联 (HR 2.441).
- 克罗恩病和性结肠炎在两个方向上都显示出与HS的显著关联.
结论:
- 在HS和IBD之间存在显著的双向风险关系.
- 患有HS的患者患上IBD的风险增加,IBD患者患上HS的风险增加.
- 这些发现强调了在HS患者中考虑IBD的重要性,反之亦然.
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