婴儿手掌超线性和2型炎症标志物预测1岁时的亚托皮炎
Iben Frier Ruge1,2, Anne-Sofie Halling1,2, Maria Rasmussen Rinnov2,3
1Department of Dermatology and Venereology, Bispebjerg Hospital, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.
概括
婴儿的超线性手掌与在生命的头两年内患上亚型皮肤炎 (AD) 的风险更高有关. 炎症的早期迹象可以进一步增加这种风险,有助于早期发现AD.
科学领域:
- 皮肤病学 皮肤病学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 识别儿科亚型皮肤炎 (AD) 的早期预测因素对于预防至关重要.
- 超线性手掌是一种临床症状,与 filaggrin 基因 (FLG) 突变和AD相关.
- 了解婴儿时期的手掌表型可能会揭示与儿童期AD的联系.
研究的目的:
- 为了确定婴儿时期明显的手掌表现型是否预测了儿童早期阿尔茨海默病的发病.
- 调查婴儿手掌纹模式与阿尔茨海默病发展之间的关联.
主要方法:
- 一组300名满期和150名早产新生儿在临床上对AD进行了监测,直到2岁.
- 在2个月时拍摄了手掌照片以进行盲目评估;分析了FLG突变和生物标志物 (TARC/CCL17).
- 危险比率 (HR) 被计算出来,以评估阿尔茨海默病发展的风险.
主要成果:
- 2个月后的超线性手掌在14.3%的婴儿中存在,并且与1岁和2岁时AD发生率的增加显著相关.
- 在调整FLG突变状态后,这种关联仍然存在.
- 超线性手掌和2个月TARC/CCL17升高的组合进一步增加了到2岁的婴儿的AD风险.
结论:
- 在2个月大时观察到的超线性手掌是第一年内儿科阿尔茨海默病风险的重要指标.
- 在2个月的2型炎症标志物的存在,以及超线性手掌,放大了发展AD的风险.
更多相关视频
09:32Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
Published on: September 26, 2019
7.3K
06:47Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
9.8K
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
01:11Papillary Dermis
3.5K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
3.5K