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慢性粒状瘤疾病中的侵入性菌感染:来自土耳其的多中心研究

Zeynep Ergenc^1,2, Sevgi Bilgic Eltan^3,4,5, Betul Gemici Karaaslan⁶

¹Pediatric Infectious Diseases, Marmara University School of Medicine, Istanbul, Türkiye.

|July 3, 2025

概括

侵袭性真菌感染 (IMI) 仍然是慢性粒状病 (CGD) 患者的主要威胁,即使有抗真菌预防措施. 这项研究揭示了土耳其CGD患者IMI诊断和管理的持续挑战.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
儿科儿科儿科

背景情况:

慢性花瘤性疾病 (CGD) 是一种罕见的原发性免疫缺陷.
侵入性菌感染 (IMI) 是CGD患者死亡的主要原因.
抗真菌预防已经改善了结果,但IMI仍然是一个重大威胁.

研究的目的:

评估土耳其CGD患者IMI的临床和真菌流行病学.
探索与CGD中的IMI相关的诊断和治疗挑战.
评估IMI对CGD患者死亡率的影响.

主要方法:

在土耳其从1991年到2022年对72名CGD患者的回顾性分析.
对人口统计,临床特征,IMI发作和抗真菌预防的评估.
使用欧洲癌症/真菌菌病研究小组标准对IMI发作进行分类.

主要成果:

在39名 (54.2%) 患者中发生了42次IMI发作,主要影响肺部.
在已证实的IMI中,Aspergillus fumigatus是最常见的病原体 (28.5%).
与X相关的CGD患者的IMI发病时间比AR-CGD更早;18.0%的死亡率与IMI有关.

结论:

尽管采取了抗真菌预防措施,但IMI仍然对CGD患者构成重大负担.
对诊断方式的获取有限,以及预防性监测中的差距都带来了挑战.
优化管理策略对于改善IMI的CGD患者的治疗结果至关重要.

关键词:

亚斯珀吉洛斯 (aspergillus) 是一种植物.慢性颗粒状细胞性疾病侵袭性真菌感染侵袭性真菌感染这是伊特拉可纳.这些是mycoses.

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