内在动态塑造了人类大脑对外部刺激的反应
Maximilian Nentwich1, Marcin Leszczynski2,3,4, Charles E Schroeder2,3
1The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, United States.
eLife
|July 3, 2025
概括
大脑的内在动态显著增强和延长神经对感官刺激的反应. 计算模型必须区分即时的感官输入和大脑自身的反复活动,以便进行准确的分析.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 大脑活动涉及到对感官刺激作出反应的反复的神经网络.
- 当前的计算模型往往无法区分直接的感官反应与内在的大脑动态.
- 了解外部刺激与内在神经活动之间的相互作用至关重要.
研究的目的:
- 开发一个计算模型,将直接的感官反应与内在的大脑动力学分开.
- 研究大脑内在的反复活动如何影响神经对外部刺激的反应.
- 分析感官和高阶大脑区域的功能连接模式.
主要方法:
- 应用一个带有外部输入 (VARX) 的矢量-自行回归模型来对人类的内记录.
- 从功能连接和编码模型中整合概念.
- 对视听刺激的神经反应的分析,包括场景剪辑,眼睛运动和声音.
主要成果:
- 内在的大脑动态增强和延长神经对感官刺激的反应.
- 如果不考虑外部输入,可能导致经常连接的错误识别.
- 与休息相比,在看电影时,反复连接性会减少.
- 外部刺激可以减少内在的神经噪声.
- 感官区域显示出主要是向外的连接,而更高阶区域显示出主要是输入的连接.
结论:
- 大脑的内在动态在处理外部视听刺激方面发挥着重要作用.
- 在休息期间观察到的内在神经活动在很大程度上解释了对外部刺激的反应.
- 准确的建模需要将外部刺激效应与内在神经动力学分开.
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