阿斯巴甜及其对人类潜在的神经认知影响
Maiah N Fogel1, Alena Khalil1, Sheikh F Khaled1
1Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, United States.
Nutrition reviews
|July 3, 2025
概括
阿斯巴甜的消费可能会导致神经毒性作用,包括记忆力受损和情绪障碍,即使是低剂量. 某些人群,如糖尿病患者,可能更容易受到伤害,需要进一步的安全研究.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 食品科学 食品科学 食品科学
背景情况:
- 作为一种常见的人工甜味剂的阿斯巴甜,面临着关于其安全性的审查.
- 在动物研究中,阿斯巴甜的分解产物与潜在的神经毒性,致癌性和代谢问题有关.
研究的目的:
- 进行关于阿斯巴甜的神经认知影响的现有文献的范围审查.
- 分析关于阿斯巴甜对大脑功能和行为的影响的研究.
主要方法:
- 在Embase,Ovid MEDLINE和Web of Science中搜索同行评审的文章.
- 在应用排除标准后包括29篇全文文章.
- 分析了动物和人类模型中神经认知影响的研究.
主要成果:
- 有证据表明,阿斯巴甜可能会诱导神经毒性作用,包括在动物模型中引起组织病理性脑部变化和高氧化应激标志物.
- 研究表明,在动物和人类模型中,记忆和学习障碍,行为功能障碍和情绪障碍 (抑郁,焦虑) 存在.
- 在食品和药物管理局 (FDA) 批准的水平或以下观察到神经认知损害,在患有先前存在的神经认知或代谢疾病的人群中,脆弱性增加.
结论:
- 阿斯巴甜的消费与潜在的神经认知不良影响有关.
- 某些人群可能面临更高的阿斯巴甜诱导的神经认知损害的风险.
- 进一步的研究是必要的,以充分理解阿斯巴甜的健康和安全影响在批准的水平.
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