患有或没有COPD的吸烟者的氧化应激:有哪些变量相关?
Aldo Pezzuto1, Alberto Ricci2, Antonella Tammaro3
1Department of Cardiovascular and Respiratory Sciences, S. Andrea Hospital, Sapienza University, Rome, Italy - pezzutoaldo@libero.it.
Minerva medica
|July 3, 2025
概括
吸烟显著增加氧化压力,与包装年和每日吸烟消费有关. 具有较高维生素D水平的吸烟者显示对这种氧化应激有保护,即使在没有慢性阻塞性肺病 (COPD) 的人中也是如此.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 香烟烟雾诱导氧化应激,导致支气管炎症和呼吸道重塑.
- 个体的抗氧化能力各不相同,反映出免疫防御状态.
- 研究了患有慢性阻塞性肺病 (COPD) 和没有慢性阻塞性肺病 (COPD) 的吸烟者的氧化应激和抗氧化能力.
研究的目的:
- 评估吸烟者的氧化应激和抗氧化能力.
- 为了比较COPD和非COPD患者之间的这些水平.
- 为了确定与吸烟者的氧化应激相关的变量.
主要方法:
- 54名患者接受了螺旋计,问卷 (CAT,mMRC,Fagestrom's) 和呼出的一氧化碳 (eCO) 测量.
- 测定了血清维生素D水平.
- 在吸烟后的唾液样本中测量了氧化应激 (d-ROM) 和抗氧化能力;基于FEV1/FVC比率<70%的COPD诊断.
主要成果:
- 在没有COPD的吸烟者中,d-ROMs值显著更高 (P<0.01).
- 没有COPD的吸烟者具有较低的维生素D水平 (P<0.03) 和较高的每日香烟摄入量和eCO (P<0.0001,P<0.01).
- 多重回归分析显示d-ROM与包装年和香烟/天相关;这些因素,以及维生素D,影响了COPD的发展.
结论:
- 烟草吸烟显然会导致氧化应激,与吸烟强度相关 (包装年,香烟/天).
- 较高的维生素D水平似乎可以保护COPD患者免受氧化应激.
- 维生素D状况,吸烟习惯和氧化应激标志物是COPD病变发生的关键因素.
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