遵守乳腺查指南和乳腺癌死亡率:一个人口队列研究
Rebecca A G Christensen1,2, Geoffrey M Anderson1,3, Shana J Kim1
1Public Health Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Breast cancer research and treatment
|July 3, 2025
概括
参与乳腺癌查,即使不严格遵守指南,也会显著降低乳腺癌死亡风险. 应该鼓励妇女参与查计划,如安大略省乳腺查计划 (OBSP).
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 基于人口的乳腺查计划可以早期发现癌症,改善治疗结果.
- 安大略省乳腺查计划 (OBSP) 已被证明可以在早期阶段诊断乳腺癌.
- 以前的研究表明查和早期癌症诊断之间存在联系,但查对死亡率的影响需要进一步调查.
研究的目的:
- 评估遵守安大略省乳腺查计划 (OBSP) 指南与乳腺癌死亡率之间的关联.
- 为了确定是否查频率影响乳腺癌死亡率,独立于诊断时的癌症阶段.
主要方法:
- 分析了2010-2017年间在安大略省被诊断患有乳腺癌的51岁及以上的48,927名妇女的队列.
- 根据OBSP指南的遵守情况,女性被分为附加,部分或非选者.
- 计算了因果特定危险比率,以评估查坚持和乳腺癌死亡之间的关系,考虑竞争风险并调整共变量.
主要成果:
- 与坚持查者相比,非查者出现的乳腺癌死亡率明显高 (HR: 3.59).
- 部分查者与坚持查者相比,乳腺癌死亡率也较高 (HR: 1.69).
- 即使是部分遵守 (至少一次查) 也与乳腺癌死亡率低于非查 (HR:0.47) 相关.
结论:
- 参与安大略省乳腺查计划 (OBSP) 与乳腺癌死亡率的降低有关,无论严格遵守指南.
- 这些发现支持鼓励妇女参与乳腺查,强调任何程度的参与都有好处.
- 该研究强调了促进乳腺癌查参与的重要性,以改善生存结果.
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