HER2阳性尿路癌:针对向药物和基于免疫疗法的组合的现有证据
Federica Ciciriello1, Gaetano Pezzicoli1, Antonello Biasi1
1Interdisciplinary Department of Medicine, University of Bari "A. Moro", Bari, Italy.
Targeted oncology
|July 3, 2025
概括
用抗体 - 药物合物 (ADC) 和免疫疗法向人体表皮生长因子受体2 (HER2) 显示出对晚期泌尿管癌 (UC) 的承诺. 将HER2向的ADC与免疫检查点抑制剂相结合,可以提高HER2阳性UC患者的生存率.
科学领域:
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期泌尿器癌 (UC) 尽管使用免疫疗法和抗体药物合物 (ADC) 等当前治疗方法,但其5年生存率很低.
- 针对可操作的突变,特别是人类表皮生长因子受体2 (HER2) 原型瘤基因,是量身定制治疗的有希望的策略.
- 在13-25%的病例中发现的HER2阳性UC,通常呈现晚,并且与预后较差有关.
研究的目的:
- 审查研究 HER2-阳性转移性UC中的 HER2-向策略的临床试验.
- 评估不同的HER2向剂的疗效,包括单克隆抗体,氨酸激酶抑制剂和ADCs.
- 探索将HER2向的ADC与高级UC的免疫治疗结合在一起的潜力.
主要方法:
- 临床试验的综合文献综述,涉及转移性UC中的HER2向疗法.
- 分析使用抗HER2单克隆抗体,铁氨酸激酶抑制剂和ADCs (特拉斯图祖马布德鲁克斯坦,迪西塔马布维多丁) 的试验数据.
- 对涉及HER2向ADC和免疫检查点抑制剂的组合策略的临床前和临床证据的审查.
主要成果:
- 在UC临床试验中,抗HER2单克隆抗体和氨酸激酶抑制剂的疗效有限.
- 针对HER2的ADC在HER2阳性转移性UC中表现出令人鼓舞的结果.
- 针对HER2的ADC与免疫疗法的联合治疗显示出协同作用的抗瘤效应,增强免疫反应并可能改变瘤微环境.
结论:
- 针对HER2的ADCs代表了高级UC的有希望的治疗途径.
- 将HER2向的ADC与免疫检查点抑制剂相结合,为治疗HER2阳性晚期UC提供了一种新且潜在的协同方法.
- 这种组合策略值得进一步研究,因为它有可能改善晚期泌尿器癌的结果.
相关概念视频
Tumor Immunotherapy
665
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
665
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Cancer Vaccines
517
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
517
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Cancer Therapies
8.0K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.0K


