药物和健康的衰老 药物和健康的衰老
Sarah N Hilmer1, Luigi Ferrucci2, Antonio Cherubini3,4
1Kolling Institute, Northern Sydney Local Health District and The University of Sydney, St. Leonards, Australia. sarah.hilmer@sydney.edu.au.
Drugs & aging
|July 3, 2025
概括
适当的药物治疗可以支持健康的衰老和功能,但证据往往排除了老年人和福祉. 未来的老年疗法可能会减缓衰老并预防疾病.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 药物治疗可以促进老年人的健康衰老和功能能力.
- 目前关于药物对衰老的疗效的证据有限,通常不代表老年人群或包括功能性结果.
- 老年人的多药性,多病性和脆弱性会导致由于治疗药物的身体,认知和社会功能受损.
研究的目的:
- 突出药物在促进健康衰老和潜在损害老年人功能方面的双重作用.
- 强调研究药物治疗的必要性,考虑不同老年人群的功能和福祉结果.
- 探索未来老年疗法在减缓衰老过程和预防慢性疾病方面的潜力.
主要方法:
- 关于药物治疗对健康衰老的影响的文献综述.
- 对有关老年人,功能性结果和多药学的证据差距的分析.
- 探索药理干预与运动和营养等非药理策略之间的相互作用.
主要成果:
- 药物可以预防和管理疾病,有助于健康的衰老.
- 某些药物会对身体和认知功能,社会互动,运动和饮食产生负面影响,特别是在患有多种疾病的脆弱老年人身上.
- 运动和营养等非药物干预措施可以减轻药物不良反应.
结论:
- 药物治疗在健康老龄化中起着至关重要的作用,但它们对功能和福祉的影响需要在代表性老年人群中进一步调查.
- 解决多药性及其不良影响对于维持衰老中的功能能力至关重要.
- 未来的老年治疗药物开发有望减缓衰老和预防慢性疾病,从而增强健康的衰老.
更多相关视频
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
2.6K
05:59Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
2.6K
相关概念视频
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
213
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
213
01:26Aging
191
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
191
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:21Factors Affecting Drug Response: Overview
2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
01:02Prescription, Nonprescription and Orphan Drugs
854
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
854
01:15Drug Abuse and Addiction: Pharmacological Phenomena
659
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
659