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关联10-2视野损失与结构和血管学参数在先进的玻璃眼

Kübra Atay Dinçer¹, Metehan Karaatlı^1,2, Onur Özalp¹

¹Department of Ophthalmology, Eskişehir Osmangazi University Medical School, Meşelik Kampüsü, Odunpazarı, Eskisehir, Turkey.

Ophthalmology and therapy

|July 3, 2025

概括

光学连贯断层扫描血管造影 (OCTA) 显示,状表面毛细管血管密度 (SCP-VD) 和状细胞综合体 (GCC) 厚度与晚期青光眼的视野MD相关. 这些OCTA参数可能有助于监测疾病进展,当视觉现场测试是困难的.

科学领域:

眼科医生眼科眼科
医疗成像医学成像
玻璃眼研究研究玻璃眼研究

背景情况:

晚期玻璃眼明显影响视觉功能.
光学连贯断层扫描血管造影 (OCTA) 为视网膜血管系统提供了新的见解.
了解青光眼的血管变化对于疾病管理至关重要.

研究的目的:

为了研究OCTA衍生的血管参数与晚期绿眼病中的功能/结构措施之间的相关性.
探索OCTA参数之间的关系,中央视野 (10-2 VF) 平均偏差 (MD),质细胞复合体 (GCC) 厚度和视网膜神经纤维层 (RNFL) 厚度.
识别潜在的替代标记物,以监测青光眼的进展.

主要方法:

对28只眼睛的回顾性,横截面研究,来自23名患有晚期青光瘤的患者 (VF MD严重于-12dB).
综合眼科检查,包括OCT,OCTA和10-2 VF测试.
皮尔森的相关性分析用于评估血管,结构和功能参数之间的关系.

主要成果:

在GCC厚度和10-2 VF MD (r=0.529,p=0.005) 之间观察到显著的正相关性.
副表面毛细管血管密度 (SCP-VD) 与10-2 VF MD (r=0.549,p=0.002) 有正相关.
斑点SCP血管面积密度与RNFL厚度相关 (r=0.429,p=0.036);视神经头层中的平均血管长度与10-2 VF MD负相关 (r=-0.528,p=0.003).
象限分析显示,SCP-VD和GCC/RNFL在上半场的厚度之间存在关联,以及深毛细管血管密度和下半场的RNFL厚度.

结论:

偏膜SCP-VD和GCC厚度显示出与10-2VFMD在晚期青光眼中的显著相关性.
这些OCTA衍生参数可以作为监测中央视觉功能的有价值的替代标记.
OCTA参数可以帮助跟踪疾病进展,特别是当标准视野测试具有挑战性时.

关键词:

晚期的玻璃眼瘤是什么?团结细胞复合体团结细胞复合体八分管血管造影 (Oct angiography) 是指八分管血管造影.在RNFL中,RNFL是最重要的.船舶密度船舶密度船舶密度视觉场视觉场视觉场视觉场

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