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Updated: Sep 17, 2025

Preparation of Primary Acute Lymphoblastic Leukemia Cells in Different Cell Cycle Phases by Centrifugal Elutriation
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环素D1过度表达诱导复制应激和微同质介导的末端结合依赖在地幔细胞淋巴瘤

Jithma P Abeykoon1,2, Shuhei Asada2, Guangli Zhu2,3

  • 1Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

The Journal of clinical investigation
|July 3, 2025
PubMed
概括

环素D1过度表达会导致复制压力和DNA损伤,促进微同质介导端结合 (MMEJ) 修复. 抑制POLQ是MMEJ的关键,在循环素D1驱动的癌症中触发了细胞亡,提供了一个治疗策略.

关键词:
细胞生物学 细胞生物学修复DNA的修复DNA的修复血液学 血液学 血液学淋巴瘤是一种淋巴瘤.

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