血液储存时间会影响在接受输血的状细胞病患者的血液学和代谢资料
Matthew S Karafin1, Abby L Grier2, Ross M Fasano3
1Department of Pathology and Laboratory Medicine, University of North Carolina (UNC) at Chapel Hill, Chapel Hill, North Carolina, USA.
在状细胞病 (SCD) 患者中使用存储较短的红细胞 (RBC) 改善了代谢和血液学参数,表明更好的输血后状态. 这项研究强调了红细胞储存时间对患者治疗结果的重要性.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 生物化学 生化学
背景情况:
- 状细胞病 (SCD) 患者通常会获得接近其储存限制的红细胞 (RBC) 单位.
- 红细胞储存时间对患者结果的影响需要进一步调查.
研究的目的:
- 确定红细胞储存时间是否会影响成人SCD患者的血液学,代谢和临床化学参数.
主要方法:
- 一个随机的双盲试验,涉及24名患有SCD的成年人接受慢性输血.
- 参与者接受了短期存储 (≤10天) 或长期存储 (≥30天) 的红血细胞.
- 分析包括代谢量,细胞因子分析和临床实验室测试.
主要成果:
- 储存短的红细胞导致了较高的2,3-双糖酸盐,最低的红细胞计数和血红蛋白A水平.
- 长期存储的红细胞与增加的氧化应激,功能障碍标志物和促炎细胞因子有关.
- 代谢学揭示了储存关键代谢途径的年龄相关变化.
结论:
- 用短存储红细胞输血导致SCD患者的代谢和血液学结果有利.
- 这些发现表明,红细胞储存时间是SCD输血疗效的关键因素.
- 短存储红细胞的代谢和炎症状况得到改善,独立于即时的临床终点.
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