现型生物衰老的CT生物标志物:新兴概念和优势
Matthew H Lee1, John W Garrett1, Daniel Liu1
1Department of Radiology, University of Wisconsin School of Medicine & Public Health, 600 Highland Ave, Madison, WI 53792.
概括
生物年龄 (BA) 可以使用计算机断层扫描 (CT) 来估计肌肉,脂肪和骨的生物标志物. 这种成像方法提供了一种实用,机会主义的方法来改进健康评估和风险预测,补充现有的脆弱性.
科学领域:
- 老年学和医学成像学
- 医疗保健中的人工智能
背景情况:
- 衰老是一个复杂的累积损伤过程,导致功能衰退和疾病风险增加.
- 年代年龄 (CA) 是医疗保健决策的关键因素,但生物年龄 (BA) 提供了更全面的健康评估.
- 现有的BA模型通常依赖于"omics"数据,但成像生物标志物仍未得到充分利用.
研究的目的:
- 探索计算机断层扫描 (CT) 生物标志物用于估计生物年龄 (BA) 的实用性.
- 突出基于CT的BA相对于传统的"omics"方法的优势.
- 强调人工智能 (AI) 在推进基于成像的BA估计中的作用.
主要方法:
- 利用肌肉,脂肪,大动脉化和骨的CT生物标志物构建基于CT的BA模型.
- 利用AI和可解释AI (XAI) 实现自动化,快速和可靠的图像分析.
- 在回顾性或前性研究中机会地应用基于成像的自动化身体构成工具.
主要成果:
- CT生物标志物提供了可访问,可重复的措施,反映了组织层面的衰老表型.
- 由人工智能驱动的自动化工具能够对成像数据进行可扩展的,人口级别的分析.
- 可解释的人工智能增强了对基于成像的BA预测的信任.
结论:
- 基于CT的表型BA估计是一种实用的,机会性的成像方法.
- 这种方法可以改善医疗决策和风险预测,超出目前的微弱学.
- 它通过提供更全面的健康评估,为社会和个人带来好处.
相关概念视频
01:26Aging
191
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
191
01:19The Effect of Aging on Tissues
2.6K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.6K
01:37Mitochondria
15.1K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
15.1K