在生物疗法下传播的偏性菌菌病
Jaime A Ibarra-Burgos1, Simón Correa-Sierra1, Sergio A Londoño-Tabares2
1Internal medicine, Universidad CES Escuela de Medicina, Medellín, Colombia.
Journal of infection in developing countries
|July 3, 2025
概括
抗瘤坏死因子 (TNF) 阿尔法疗法可以增加严重感染的风险,如偏皮性菌症. 这一案例凸显了早期诊断和治疗患者服用抗TNFα药物的重要性.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 帕拉科西多伊多米科斯是中美洲和南美洲流行的一种流行性菌根病.
- 抗瘤坏死因子 (TNF) α剂广泛用于自身免疫性疾病.
- 众所周知,这些药物增加了严重机会性感染的风险.
研究的目的:
- 报告在接受抗TNFα治疗的患者中发生的帕拉科西迪奥伊多米科斯病例.
- 为了强调抗TNFα药物与严重的真菌感染之间的潜在关联.
- 提高免疫功能低下患者对机会性感染的认识.
主要方法:
- 一个71岁的哥伦比亚男性农民的案例研究,患有口腔病变和慢性咳.
- 诊断程序包括活检,血清免疫扩散测试,介质镜和肺活检.
- 微生物染色和其他感染的测试最初是负的.
主要成果:
- 活检显示了颗粒状炎症;然而,最初没有发现任何微生物.
- 一个高位数 (1:256) 的Paracoccidioides抗体证实了诊断.
- 组织病理学显示,芽的酵母在特有的"船长轮"形成.
结论:
- 抗TNFα疗法与机会性感染的风险增加有关,比如对菌菌菌.
- 早期识别和及时治疗对于有利的患者结果至关重要.
- 这一案例强调了在接受免疫抑制治疗的患者中诊断真菌感染时需要保持警.
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