慢性乙型肝炎的HBeAg清除:这是可以预测的吗?
Tuba İlgar1, Aybegüm Özşahin2, Sudem Mahmutoğlu Çolak2
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Türkiye.
Journal of infection in developing countries
|July 3, 2025
概括
预测乙型肝炎e抗原 (HBeAg) 损失是慢性乙型肝炎 (CHB) 治疗的关键. AST-血小板比率指数 (APRI) 和FIB-4分数,以及血小板数,是HBeAg清除的显著预测指标.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 临床医学 临床医学
背景情况:
- 乙型肝炎e抗原 (HBeAg) 损失是慢性乙型肝炎 (CHB) 预后的关键标志物.
- 准确预测HBeAg清除有助于优化抗病毒治疗持续时间和患者管理.
- 确定可靠的预测因素对于个性化CHB治疗至关重要.
研究的目的:
- 确定预测HBeAg清除的临床和生化因素,在接受抗病毒治疗的HBeAg阳性CHB患者中.
- 评估各种评分系统的预测性能,包括APRI和FIB-4,用于HBeAg损失.
主要方法:
- 在2008-2022年期间接受抗病毒治疗的94名HBeAg阳性CHB患者的回顾性分析.
- 参数的评估:年龄,血小板数,治疗时间,肝酶 (ALT,AST),ALBI,PALBI,APRI和FIB-4.
- 接收器操作特征 (ROC) 分析,以确定已识别的HBeAg损失因素的预测能力.
主要成果:
- 在34%的患者中观察到HBeAg清除,治疗持续时间较长.
- 获得HBeAg清除的患者年龄较大,在治疗开始时具有较高的APRI和FIB-4中位数.
- ROC分析证实年龄,FIB-4,血小板数和APRI是显著的预测因素,APRI显示出最高的预测值 (AUC=0.771).
结论:
- AST-血小板比率指数 (APRI) 和FIB-4是预测CHB患者HBeAg清除的有价值的非侵入性标记.
- 血小板数和患者年龄也有助于预测HBeAg损失.
- 这些发现支持在临床决策中使用APRI和FIB-4来优化CHB治疗.
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