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Updated: Sep 17, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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SFTSV的非结构蛋白通过破坏DPP9-介导的三元复合体来激活NLRP1和CARD8炎症体

Pan-Pan Liu1, Shu-Peng Jiang2, Bang Li1

  • 1State Key Laboratory of Virology, School of Public Health, Wuhan University, Wuhan, China.

PLoS pathogens
|July 3, 2025
PubMed
概括

传播的布尼亚病毒SFTSV通过破坏DPP9抑制复合体来激活NLRP1和CARD8炎症体. 病毒NSs蛋白向FIIND域,降解DPP8/9,并释放炎性酶招募域 (CARD) 进行免疫信号传递.

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