与代谢功能障碍相关的脂肪性肝病中的心脏代谢功能障碍负担和死亡结果
1Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.
PloS one
|July 3, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 的高心脏代谢功能障碍负担显著增加死亡风险. 监测血糖和血压对于管理MASLD患者和改善生存结果至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 越来越被认可,心脏代谢功能障碍发挥着中心作用.
- 了解心脏代谢风险因素对MASLD预后的影响对于患者管理至关重要.
研究的目的:
- 为了研究心脏代谢功能障碍的负担与被诊断为MASLD的个体的死亡结果之间的关联.
- 确定在MASLD人群中最显著影响生存的特定心脏代谢风险因素.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) 数据库 (1999-2018) 的9017名患有MASLD的参与者的数据分析.
- 使用卡普兰-梅尔曲线和基于心脏代谢风险因素数量的考克斯回归分析对死亡结果的比较.
- 在115个月的中位随访期内评估所有原因和心血管特定死亡率.
主要成果:
- 与具有5个心脏代谢风险因素的参与者相比,与具有1个风险因素的参与者相比,所有原因死亡率 (aHR=3.57) 和心血管死亡率 (aHR=7.72) 显著增加.
- 血糖或血压的异常与具有相似数量的风险因素的个体中最低的生存率有关.
- 发现患有MASLD的年轻人更容易受到心脏代谢功能障碍的不良预后影响.
结论:
- 在MASLD患者中,心脏代谢功能障碍的高负担与死亡率大幅增加有关.
- 对心脏代谢功能障碍的临床评估,重点关注血糖和血压,对于MASLD的有效管理策略至关重要.
- 对心脏代谢风险因素的早期识别和干预对于改善MASLD患者的长期生存至关重要.
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