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Updated: Sep 17, 2025

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合成和初步抗癌评价的提亚二林的提亚衍生物

Yuting Zhang1, Jun Zhang1, Siwei Ji2

  • 1School of Biological and Chemical Engineering, Yangzhou Polytechnic College, Yangzhou, China.

Natural product research
|July 3, 2025
PubMed
概括

研究人员合成了具有强大的抗癌性质的新型迪菲林 thiazole 衍生物. 化合物5d和5e对HepG2癌细胞表现出显著的细胞毒性,并抑制了V-ATPase.

关键词:
在Diphyllin中使用.细胞毒性药物 细胞毒性药物综合合成是一种合成.醇的衍生品 醇衍生品

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the...
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