对比的表示学习用于跨域血细胞图像分类与否定机制
IEEE journal of biomedical and health informatics
|July 3, 2025
概括
新的CD-CBC框架通过整合对比学习和denoising来提高不同成像条件的白细胞分类准确性. 这种方法提高了血液疾病和血液恶性瘤的诊断能力.
科学领域:
- 血液学 血液学 血液学
- 医学图像分析 医学图像分析
- 机器学习 机器学习
背景情况:
- 准确的白细胞识别对于诊断血液疾病至关重要.
- 目前使用掩盖自动编码器 (MAE) 的方法与域移位和不准确的特征分布学习相斗争.
- 染色,照明和显微镜设置的变化挑战了现有模型的概括性.
研究的目的:
- 开发一个强大的框架,CD-CBC,用于跨域白细胞图像分类.
- 在不同的成像条件下提高血细胞分类模型的概括能力.
- 通过先进的图像分析,提高诊断血液恶性瘤和血液疾病的准确性.
主要方法:
- 拟议的CD-CBC框架整合了对比表示学习和拒绝机制.
- 使用基于LoRA的分段任何模型 (LoRA-SAM) 来减少背景噪音和血小板干扰.
- 采用了对比性掩盖自编码器 (CMAE) 来进行细粒度特征提取和空间关系建模.
- 引入了一个潜伏空间无声化机制来完善特征分布学习.
主要成果:
- 在血液细胞图像分类中实现了卓越的跨域性能.
- 达到62.47%的平均准确率,比最先进的性能高出3.17%.
- 在两个基准数据集中表现出强大的概括能力.
结论:
- CD-CBC有效地解决了血液细胞图像分类中的域转移挑战.
- 拟议的框架提高了血液病的诊断准确度.
- 该方法显示出在血液学中的实际临床应用的巨大潜力.
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