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Updated: Sep 17, 2025

Spatiotemporally Controlled Nuclear Translocation of Guests in Living Cells Using Caged Molecular Glues as Photoactivatable Tags
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挖掘CRBN目标空间重新定义了分子引新基质识别的规则

Georg Petzold1, Pablo Gainza1, Stefano Annunziato1

  • 1Monte Rosa Therapeutics Inc, Boston, MA, USA.

Science (New York, N.Y.)
|July 3, 2025
PubMed
概括

针对CRL4CRBN的分子粘合剂重新编程特异性以降解蛋白质. 这项研究扩大了cereblon (CRBN) 的目标空间,确定了新的认可规则和1600多种潜在的新基质用于药物开发.

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Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
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