脑垂体腺瘤患者的静脉血栓栓塞:英国多中心队列研究
Kristina Isand1,2,3, Riccardo Pofi4, Oliver Haermson2
1Institute of Biomedicine and Translational Medicine, University of Tartu, Ülikooli 18, Tartu 50090, Estonia.
European journal of endocrinology
|July 3, 2025
概括
与其他垂体疾病相比,患有库辛病 (CD) 的患者患有静脉血栓栓塞 (VTE) 的风险显著更高. 糖尿病是一种独立的风险因素VTE在CD患者.
科学领域:
- 内分泌学 在内分泌学.
- 血管医学 血管医学
- 在瘤学瘤学.
背景情况:
- 垂体腺瘤是常见的瘤,具有不同的临床影响.
- 静脉血栓塞栓症 (VTE) 是一种严重的并发症,具有多因素的原因.
- 库辛病 (CD) 与代谢障碍有关,可能会增加静脉瘤风险.
研究的目的:
- 为了比较患有库辛病 (CD) 患者的VTE风险与壮症和非功能性垂体腺瘤 (NFPAs) 的风险.
- 为了确定特定的风险因素和VTE在CD患者的时间.
主要方法:
- 追溯,观察性队列研究,包括来自英国3个中心的827名患者 (2010-2021年).
- 使用千平方试验和考克斯回归方法对VTE累积发病率进行比较.
- 对与VTE发展相关的临床因素的分析.
主要成果:
- 在CD中,VTE发病率为11.2%,在壮病中为2.7%,在NFPA中为0.4%.
- 慢性病患者的VTE风险明显更高 (OR 21.05与NFPA相比,OR 4.48与壮症相比).
- 慢性病诊断 (HR 46.87) 和糖尿病/葡萄糖耐受性受损 (HR 3.48) 是重要的静脉瘤风险因素. 在CD中,大多数VTE发生在诊断或手术后1年内.
结论:
- 与壮病和NFPA相比,库辛氏病显著增加了静脉瘤风险.
- 糖尿病是CD中VTE的一个独立风险因素.
- 在CD中的VTE通常发生在诊断或外科手术期间,突出显示关键的监测期.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
41
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
41
Venous Thrombosis III: Interprofessional Care
26
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
26
Venous Thrombosis I: Introduction
45
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
45
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
46
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
46
The Pituitary Gland
7.3K
The pituitary is a small endocrine organ in the sphenoid bone under the hypothalamus. Primarily, the pituitary in adults has two distinct anatomical and functional regions— the anterior and posterior lobes. During human fetal development, a third pituitary gland region called the pars intermedia atrophies and disappears. However, some of its cells migrate and exist adjacent to the anterior pituitary in adults.
7.3K
Aneurysm II: Clinical Manifestations and Diagnostic Studies
26
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
26


