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Updated: Sep 17, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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设计,合成,抗癌活性,以及基于伊米达佐的新衍生物的in silico计算研究,这些衍生物具有潜在的多目标激酶抑制活性

Nesreen S Ahmed1, Somaia S Abd El-Karim1, Manal M Anwar1

  • 1Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), El Bohouth St., Dokki, Cairo 12622, Egypt.

Bioorganic & medicinal chemistry
|July 3, 2025
PubMed
概括

合成了针对结肠癌激酶的新型化合物. 化合物1c和2h显示出强大的抗增殖作用和多酶抑制,2h还诱导了细胞亡和细胞循环停止,表明了新的癌症疗法的潜力.

关键词:
它具有抗增殖效果的作用.结肠癌是什么意思 结肠癌是什么意思动态模拟的动态模拟.伊米达-4-一个分子对接是分子对接.多酶抑制剂 多酶抑制剂

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