过氧化铜触发的活性有效增强了协同作用的化学动力学免疫疗法
Yanfei Zhu1, Nan Wang2, Hanjie Zhang3
1School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China; State Key Laboratory of Respiratory Health and Multimorbidity, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, PR China.
Journal of colloid and interface science
|July 3, 2025
概括
这项研究将化学动力学疗法 (CDT) 与使用新型纳米载体的免疫疗法结合起来. 该方法将活性氧物种 (ROS) 转化为活性物种 (RNS),以增强瘤细胞的杀死和免疫反应.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 化学动力学疗法 (CDT) 面临的局限性是由于短寿命的活性氧物种 (ROS) 和生物可用性差.
- 开发有效的癌症治疗需要策略来克服这些局限性并提高治疗结果.
研究的目的:
- 制定一个协同策略,将CDT与免疫治疗结合起来.
- 设计一种多功能纳米载体,以增强瘤细胞杀死和免疫反应激活.
主要方法:
- 制造一个多功能纳米载体 (HMSN-Met@HA-CuO2),用于联合输送甲胺和CuO2.2.
- 使用CuO2来放大细胞内ROS生成并诱导cuproptosis.
- 使用甲胺 (Met) 释放氧化 (NO),将ROS转化为更稳定的活性物种 (RNS).
主要成果:
- 该纳米载体成功产生ROS并诱导了cuproptosis.
- 通过NO将ROS转化为RNS导致脂质,蛋白质和DNA的持续损伤.
- 证明了强大的瘤细胞细胞毒性和抗瘤免疫反应的激活.
- 通过结合的CDT和免疫疗法方法实现了显著改善的抗瘤疗效.
结论:
- 开发的纳米载体系统有效地将氧基转化为基.
- 这一策略增强了CDT和免疫疗法的联合应用,以提高抗瘤疗效.
- 突出了ROS-to-RNS转换在癌症治疗中的潜力.
相关概念视频
Combined Effects of Drugs: Synergism
4.8K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
4.8K
Tumor Immunotherapy
665
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
665
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)

