通过综合流行率和因果关联,将阻塞性睡眠呼吸暂停与肺高血压联系起来:系统性审查,元分析和门德尔随机化
Dongru Du1, Jiangyue Qin2, Xueru Hu3
1Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, PR China; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, 610041, PR China.
Heart & lung : the journal of critical care
|July 3, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与肺高血压 (PH) 有因果关系,这两种疾病的患病率都很高. 需要进一步的研究来证实这种关系及其临床意义.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 遗传学 是一个遗传学.
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和肺高血压 (PH) 经常同时存在.
- 需要进一步调查OSA和PH之间的双向因果关系.
研究的目的:
- 为了确定PH在OSA患者中和OSA在PH患者中PH的患病率.
- 使用孟德尔随机化 (MR) 调查OSA和PH之间的双向因果关系.
主要方法:
- 系统审查PubMed,科学网络和Scopus的流行数据.
- 孟德尔随机化分析使用综合性流行病学部门和芬恩根队列的数据.
- 逆方差加权 (IVW) 方法作为主要的MR分析方法,补充了MR-Egger回归和灵敏度分析.
主要成果:
- 在OSA患者中PH的综合患病率为36%,在PH患者中OSA为34%.
- 患有OSA-PH重叠的患者表现出较低的FEV1/FVC,男性性别,年龄较大,BMI较高和更大的呼吸暂停-呼吸暂停指数.
- MR分析表明OSA对PH的因果作用,但不是反之.
结论:
- OSA和PH是高度流行的并发症,具有显著的重叠.
- OSA与PH有因果关系,这表明OSA是PH发展的潜在风险因素.
- 需要进一步的前性和机制性研究来确认因果关系和临床影响.
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