压力对患有酒精使用障碍和没有酒精使用障碍的人的认知灵活性的影响为零
Erica N Grodin1, Dylan E Kirsch2, Steven Nieto2
1Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Drug and alcohol dependence
|July 3, 2025
概括
急性压力对患有或没有酒精使用障碍 (AUD) 的人的认知灵活性没有影响. 然而,与对照人群相比,患有AUD的人在压力期间表现出前带带皮层激活率降低.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 压力是已知的酒精消费的触发因素,与认知灵活性障碍有关.
- 以前关于压力和认知灵活性的研究主要集中在临床前模型上.
- 将这些发现转化为人类临床样本对于理解酒精使用障碍 (AUD) 至关重要.
研究的目的:
- 研究急性压力对AUD和没有AUD的个体认知灵活性的影响.
- 在急性压力期间探索AUD和无AUD个体之间的神经电路差异.
主要方法:
- 65名参与者 (34名AUD,31名对照人) 完成了威斯康星卡片排序任务在压力之前和之后.
- 蒙特利尔成像压力任务与fMRI被用来诱导压力.
- 重复测量ANCOVA和全脑分析评估了压力,群体和相互作用对认知灵活性和神经反应的影响.
主要成果:
- 两组都报告了增加的压力,没有显著的压力-每个组的相互作用.
- 没有发现压力,群体或它们的相互作用对认知灵活性有显著影响.
- 与AUD组相比,对照组在压力期间表现出较大的前带带皮层激活.
结论:
- 急性压力似乎不会影响有或没有AUD的个体的认知灵活性.
- 患有AUD的个体在压力时表现出前带带皮层活化减少.
- 这表明在AUD的压力期间可能有不同的自上而下的处理招聘.
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