纤维细胞-心血管系统的新兴治疗点?
Sebastiaan E J Asselberghs1, Maurice Halder2, Rafael Kramann3
1Department of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands; Department of Vascular Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
Pharmacological reviews
|July 3, 2025
概括
心血管系统中的纤维细胞多样化,在心脏和血管健康和疾病中发挥关键作用. 更好地理解和命名这些细胞类型可能会导致新的精确疗法.
科学领域:
- 心血管生物学 心血管生物学
- 细胞异质性 细胞异质性
- 纤维细胞研究 纤维细胞研究
背景情况:
- 单细胞RNA测序揭示了纤维细胞在整个心血管系统中是异质的和可塑的.
- 纤维细胞在矩阵生产之外有各种各样的作用,包括炎症信号和表型切换.
研究的目的:
- 综合有关纤维细胞异质性和心血管健康和疾病调节的当前知识.
- 突出需要共识命名法和改善纤维细胞亚群的标记.
主要方法:
- 对单细胞RNA测序和纤维细胞研究近期进展的回顾.
- 综合了有关纤维细胞在健康和疾病心脏和血管状态中的作用的数据.
主要成果:
- 纤维细胞亚种群在心脏和血管组织中表现出共同的标记物,呈现出治疗潜力和安全问题.
- 临床前研究表明心脏纤维细胞向有前途,但血管干预是有限的.
- 缺乏共识的命名体系阻碍了进步,原因是重叠的表型和不同的功能.
结论:
- 纤维细胞子集的精细表征和命名对于利用心血管疾病的治疗潜力至关重要.
- 需要改进纤维细胞特异性标记物,以最大限度地减少非目标效应并提高治疗精度.
- 关于纤维细胞命名和标记特异性的共识对于推进精确心血管医学至关重要.
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